We spoke with neurologist Esther Bui from Canada about her work to improve neurological health for women.

Walking the Talk for Dementia is no ordinary conference, but an experience that is designed to bring together people with diverse perspectives on dementia, including people with lived experience, and to foster new ways of thinking and collaborating. We asked founder Fernando Aguzzoli-Peres to tell us more about his unique initiative.

Researchers have developed a CRISPR–Cas9-based epigenetic editing approach that sensitizes glioblastoma cells to standard chemotherapy drugs and could improve the treatment of tumours that have developed resistance to these drugs.

The use of bioengineered implants has provided insight into the immunological processes that underlie progression in multiple sclerosis.

A case–control study has found that lesions in a specific hippocampal circuit cause psychosis. This circuit could represent a novel therapeutic target for conditions such as schizophrenia.

A new paper presents insights from an individual who survived to an advanced age without developing dementia, despite the presence of genetic risk factors for Alzheimer disease and substantial amyloid pathology in the brain.

Measurements of neurofilament light chain, glial fibrillary acidic protein and contactin 1 in plasma can provide useful prognostic information following traumatic spinal cord injury, according to new research.

A recent article reports the successful prenatal treatment of a child with spinal muscular atrophy type 1.

New research suggests that pathological α-synuclein in Parkinson disease can propagate from kidney to brain.

Implementation of patient and public involvement and engagement (PPIE) to enable patients and carers to feel included and equal to healthcare professionals is challenging to do well. Here, leaders of a PPIE group share their lived experience and highlight the importance of addressing the needs of all participants to enable true partnership.

Patient and public involvement and engagement is increasingly mandated in funding applications, yet often remain tokenistic and transitory. Working with patient and public contributors requires investment, thought, care and time. We discuss approaches that aim to increase agency for coresearchers, with the goal of strengthening public confidence and trust in research.