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    The MICrONS Project set out to create a massively dense reconstruction of the structural connections and functions of an entire millimeter volume of mouse visual cortex, along with new artificial intelligence-driven tools.

    Image: Forrest Collman; Microns Consortium

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    Spatial proteomics is our pick for Method of the Year 2024, for the impact that these technologies have had on the understanding of the organization, structure and function of complex tissues, including in global tissue atlas projects.

    Image: Elham Karimi and Simon Milette, from the Walsh and Quail Labs, Rosalind and Morris Goodman Cancer Institute

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    Established in 2016, the Human Cell Atlas (HCA) consortium set out to create a comprehensive biological map of cells within the human body.

    Image: Claire Agosti/SayoStudio; Concept: Ania Hupalowska

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    The 2024 Nobel Prize in Chemistry has been awarded to David Baker “for computational protein design” and to Demis Hassabis and John M. Jumper “for protein structure prediction”.

    Image: Springer Nature/The Nobel Foundation/Imagesource

  • Collection |

    The Nobel Prize in Physics 2024 has been awarded to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks”.

    Image: Springer Nature/The Nobel Foundation/Imagesource

  • Collection |

    The 2024 Nobel Prize in Physiology or Medicine has been awarded jointly to Victor Ambros and Gary Ruvkun "for the discovery of microRNA and its role in post-transcriptional gene regulation".

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    Advanced artificial intelligence (AI)-based methods are having a transformative impact on biological research.

    Image: Weiquan Lin / Getty Images

  • Collection |

    From the generation of embryo-like structures to the establishment of cell-based approaches to model or treat disease, the field of stem cell and developmental biology has impressively progressed during the past few months.

    Image: Jacob Hanna and Maayan Visuals – Oldak B. et al. Complete human day 14 post-implantation embryo models from naive ES cells. Nature 622, 562–573 (2023). https://www.nature.com/articles/s41586-023-06604-5

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    Detailed method reporting is essential for research reproducibility and trust in published results.

    Image: Sam Whitham

  • Focus |

    Methods for modeling development is our Method of the Year 2023, for the remarkable insights that recent methodological advances have enabled in our understanding of the molecular mechanisms of human embryogenesis.

    Image: Berna Sozen, Zernicka-Goetz Lab