KEGG ORTHOLOGY: K08530

ORTHOLOGY: K08530

Entry

K08530                      KO

Symbol

NR1C3, PPARG

Name

peroxisome proliferator-activated receptor gamma

Pathway

map03320

PPAR signaling pathway

map04148

Efferocytosis

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04380

Osteoclast differentiation

map04714

Thermogenesis

map04932

Non-alcoholic fatty liver disease

map05016

Huntington disease

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05216

Thyroid cancer

map05417

Lipid and atherosclerosis

Disease

H00032

Thyroid cancer

H00409

Type 2 diabetes mellitus

H00420

Familial partial lipodystrophy

H02106

Genetic obesity

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09149 Aging
   04211 Longevity regulating pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09159 Environmental adaptation
   04714 Thermogenesis
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
   05202 Transcriptional misregulation in cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09162 Cancer: specific types
   05216 Thyroid cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09164 Neurodegenerative disease
   05016 Huntington disease
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
Nuclear receptors [BR:ko03310]
1. Thyroid hormone like
  1C. Peroxisome proliferator-activated receptor (PPAR)
   K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma

Genes

HSA:	5468(PPARG)

PTR:	460178(PPARG)

PPS:	100974825(PPARG)

GGO:	101134077(PPARG)

PON:	100171496(PPARG)

PPYG:

129032700(PPARG)

NLE:	100581046(PPARG)

HMH:	116466751(PPARG)

SSYN:

129471106(PPARG)

MCC:	574190(PPARG)

MCF:	102120453(PPARG)

MTHB:

126949058

MNI:	105477726(PPARG)

CSAB:

103228027(PPARG)

CATY:

105585799(PPARG)

PANU:

101012073(PPARG)

TGE:	112619480(PPARG)

MLEU:

105542171(PPARG)

RRO:	104673295(PPARG)

RBB:	108517991(PPARG)

TFN:	117083265(PPARG)

PTEH:

111546909(PPARG)

CANG:

105519098(PPARG)

CJC:	100414099(PPARG)

SBQ:	101028278(PPARG)

CIMI:

108284639(PPARG)

ANAN:

105730772(PPARG)

CSYR:

103263751(PPARG)

MMUR:

105882670(PPARG)

LCAT:

123638104(PPARG)

PCOQ:

105819019(PPARG)

OGA:	100943160(PPARG)

MMU:	19016(Pparg)

MCAL:

110295901(Pparg)

MPAH:

110317409(Pparg)

RNO:	25664(Pparg)

MCOC:

116099428(Pparg)

ANU:	117715534(Pparg)

ASYL:

127679069(Pparg)

MUN:	110550822(Pparg)

CGE:	100689245(Pparg)

MAUA:

101829400(Pparg)

PROB:

127236259(Pparg)

PLEU:

114689632(Pparg)

MORG:

121437699(Pparg)

MFOT:

126505512

AAMP:

119807937(Pparg)

NGI:	103751484(Pparg)

HGL:	101711078(Pparg)

CPOC:

100729138(Pparg)

CCAN:

109694945(Pparg)

DORD:

105981285(Pparg)

DSP:	122107985(Pparg)

PLOP:

125358817(Pparg)

NCAR:

124971234

MMMA:

107150087(Pparg)

ITI:	101976929(Pparg)

OCU:	100008892(PPARG)

OPI:	101533802(PPARG)

TUP:	102495121(PPARG)

GVR:	103590613(PPARG)

CFA:	403606(PPARG)

CLUD:

112661459(PPARG)

VVP:	112933683(PPARG)

VLG:	121494412(PPARG)

NPO:	129521806(PPARG)

AML:	100482938(PPARG)

UMR:	103669544(PPARG)

UAH:	113257185(PPARG)

UAR:	123801980(PPARG)

ELK:

111144031

LLV:

125108518

MPUF:

101688974(PPARG)

MNP:	132011568(PPARG)

MLK:	131824235(PPARG)

NVS:	122909195(PPARG)

ORO:	101370284(PPARG)

EJU:	114207745(PPARG)

ZCA:	113918247(PPARG)

MLX:	118005676(PPARG)

NSU:	110585024(PPARG)

LWW:

102742585

FCA:	101095161(PPARG)

PYU:	121041247(PPARG)

PCOO:

112859366(PPARG)

PBG:	122487517(PPARG)

PVIV:

125154732(PPARG)

LRUF:

124524538

LGF:	123605991(PPARG)

AJU:

106977134

PTG:	102957164(PPARG)

PPAD:

109254341(PPARG)

PUC:

125930730

PLEZ:

122203895(PPARG)

HHV:	120231290(PPARG)

BTA:	281993(PPARG)

BOM:	102265537(PPARG)

BIU:	109576385(PPARG)

BBIS:

105004745(PPARG)

CHX:	100861309(PPARG)

OAS:	443513(PPARG)

BTAX:

128048702(PPARG)

CSUM:

138086941(PPARG)

ODA:	120868104(PPARG)

CCAD:

122424564(PPARG)

MREE:

136167869(PPARG)

OVR:	110124204(PPARG)

MBEZ:

129547724(PPARG)

SSC:	397671(PPARG)

CFR:	102516350(PPARG)

CBAI:

105067470(PPARG)

CDK:	105093103(PPARG)

VPC:	102544597(PPARG)

BACU:

103013413(PPARG)

BMUS:

118903688(PPARG)

LVE:	103085722(PPARG)

OOR:

101272154

LALB:

132526781(PPARG)

DLE:

111168952

PCAD:

102986529(PPARG)

PSIU:

116762744(PPARG)

NASI:

112396459(PPARG)

ECB:	100051258(PPARG)

EPZ:	103554547(PPARG)

EAI:	106829341(PPARG)

MYB:	102254594(PPARG)

MYD:	102771129(PPARG)

MMYO:

118668073(PPARG)

MLF:	102435787(PPARG)

MDT:	132215431(PPARG)

MYUM:

139022444(PPARG)

PKL:	118715228(PPARG)

EFUS:

103295703(PPARG)

MNA:	107534765(PPARG)

DRO:	112301119(PPARG)

SHON:

118990275(PPARG)

AJM:	119044811(PPARG)

PDIC:

114501975(PPARG)

PHAS:

123814448(PPARG)

MMF:	118633087(PPARG)

PPAM:

129088213(PPARG)

HAI:	109384577(PPARG)

RFQ:	117037017(PPARG)

PALE:

102892450(PPARG)

PGIG:

120621474(PPARG)

PVP:	105299024(PPARG)

RAY:	107519731(PPARG)

MJV:	108394347(PPARG)

TOD:	119255673(PPARG)

SARA:

101544894(PPARG)

SFUM:

130037611(PPARG)

SETR:

125998082(PPARG)

LAV:	100654408(PPARG)

TMU:

101356506

ETF:	101656886(PPARG)

DNM:	101418117(PPARG)

MDO:	100025091(PPARG)

GAS:	123239366(PPARG)

SHR:	100934154(PPARG)

AFZ:

127552073

PCW:	110204887(PPARG)

TVP:	118830830(PPARG)

PBRV:

138158043(PPARG)

OAA:	100080852(PPARG)

TACU:

119950190(PPARG)

GGA:	373928(PPARG)

PCOC:

116239018(PPARG)

MGP:	100540960(PPARG)

CJO:	107319697(PPARG)

TPAI:

128078653(PPARG)

LMUT:

125698859(PPARG)

NMEL:

110404711(PPARG)

APLA:

101792429(PPARG)

ACYG:

106040065(PPARG)

CATA:

118253741(PPARG)

AFUL:

116493021(PPARG)

TGU:	100231741(PPARG)

LSR:	110470665(PPARG)

SCAN:

103816936(PPARG)

PMOA:

120501784(PPARG)

OTC:	121348250(PPARG)

PRUF:

121349064(PPARG)

ATRC:

139596062(PPARG)

GFR:	102035311(PPARG)

FAB:	101815733(PPARG)

OMA:	130258140(PPARG)

PHI:	102104364(PPARG)

PMAJ:

107210458(PPARG)

CCAE:

111935235(PPARG)

CCW:	104695746(PPARG)

CBRC:

103617698(PPARG)

ACOE:

138117369(PPARG)

ETL:	114059219(PPARG)

ZAB:	102062499(PPARG)

ZLE:	135453331(PPARG)

ACHL:

103800408(PPARG)

SVG:	106849277(PPARG)

MMEA:

130582954(PPARG)

HRT:	120758135(PPARG)

SATI:

136366091(PPARG)

CCIC:

134048589(PPARG)

FPG:	101911405(PPARG)

FCH:	102051838(PPARG)

CCRI:

104163001(PPARG)

NNT:	104405273(PPARG)

SHAB:

115614322(PPARG)

ACUN:

113484975(PPARG)

TALA:

104358503(PPARG)

ACHC:

115333378(PPARG)

HALD:

104316809(PPARG)

HLE:	104842229(PPARG)

AGEN:

126049793

HHAR:

128137449(PPARG)

GCL:

127021597

CSTI:

104560598(PPARG)

LDI:	104345998(PPARG)

MNB:	103772206(PPARG)

DPUB:

104301898(PPARG)

PPUS:

135182338(PPARG)

AVIT:

104268687(PPARG)

BRHI:

104489483(PPARG)

EGZ:	104124309(PPARG)

NNI:	104022931(PPARG)

PCRI:

104030690(PPARG)

PCAO:

104052479(PPARG)

PADL:

103915212(PPARG)

AFOR:

103905410(PPARG)

FGA:	104083834(PPARG)

GSTE:

104259627(PPARG)

CLV:	102097513(PPARG)

MUI:	104547270(PPARG)

PGUU:

104458906(PPARG)

PLET:

104619602(PPARG)

EHS:	104510785(PPARG)

CMAC:

104483818(PPARG)

CUCA:

104064614(PPARG)

TEO:	104375714(PPARG)

BREG:

104631025(PPARG)

OHA:	104335219(PPARG)

ACAR:

104527114(PPARG)

CPEA:

104398704(PPARG)

CVF:	104290774(PPARG)

RTD:	128915559(PPARG)

CRID:

134521423(PPARG)

AAM:	106488868(PPARG)

AROW:

112966385(PPARG)

NPD:	112953033(PPARG)

TGT:	104570320(PPARG)

DNE:	112982856(PPARG)

SCAM:

104152697(PPARG)

ASN:	102375364(PPARG)

AMJ:	102575176(PPARG)

CPOO:

109311369(PPARG)

GGN:	109289149(PPARG)

PSS:	102460093(PPARG)

CMY:	102947653(PPARG)

CCAY:

125640259(PPARG)

DCC:	119858679(PPARG)

CPIC:

101930880(PPARG)

TST:	117880722(PPARG)

CABI:

116820240(PPARG)

MRV:	120369318(PPARG)

ACS:	100557020(pparg)

ASAO:

132769226(PPARG)

PVT:	110083807(PPARG)

SUND:

121923490(PPARG)

PBI:	103056230(PPARG)

CTIG:

120307441(PPARG)

TSR:

106542303

PGUT:

117677749(PPARG)

APRI:

131190252(PPARG)

PTEX:

113452816(PPARG)

NSS:	113418162(PPARG)

VKO:	123034221(PPARG)

PMUA:

114591638(PPARG)

PRAF:

128408257(PPARG)

ZVI:	118080667(PPARG)

HCG:	128341701(PPARG)

GJA:	107118018(PPARG)

STOW:

125430296(PPARG)

EMC:	129328994(PPARG)

XLA:	108704417(pparg.S) 397769(pparg.L)

XTR:	100144687(pparg)

NPR:	108785475(PPARG)

RTEM:

120945275(PPARG)

BBUF:

120979231(PPARG)

BGAR:

122943713(PPARG) 122944170

PWL:	138259136(PPARG)

MUO:	115472661(PPARG)

GSH:	117351257(PPARG)

DRE:	557037(pparg)

SRX:	107742034 107758005(pparg)

SANH:

107667870 107687310(pparg)

SGH:	107564291(pparg) 107571218

CCAR:

109081042(pparg) 109103539

CAUA:

113054937 113068124

CGIB:

127968264 128022687

PTET:

122353721(pparg)

LROH:

127172994(pparg)

OMC:	131549247(pparg)

PPRM:

120460662(pparg)

RKG:	130100903(pparg)

MAMB:

125256953(pparg)

CIDE:

127522955

CERY:

137021817(pparg)

MASI:

127425947 127427834

TROS:

130571051(pparg)

TDW:	130409996(pparg)

MANU:

129427338(pparg)

PDAB:

135747333(pparg)

IPU:	108254912 108276331

IFU:	128619537 128625377(pparg)

PHYP:

113537934(pparg) 113545604

SMEO:

124398892 124402213(pparg)

TFD:	113639085(pparg) 113650910

TVC:	132837723(pparg) 132862287

CGAR:

128509991 128511083(pparg)

NGRA:

132874246(pparg)

TRN:	134302019(pparg) 134333976

AMEX:

103026166 103030663(pparg)

CMAO:

118799664(pparg) 118822119

EEE:	113589601(pparg)

CHAR:

105900157 105905121(pparg)

SPIL:

134087481 134091979(pparg)

TRU:	100049069(pparg)

TFS:	130523681(pparg)

TNG:	GSTEN00027585G001

LCO:	104919339(pparg)

NCC:	104947475(pparg)

TBEN:

117489566(pparg)

CGOB:

115008299(pparg)

PGEO:

117446794(pparg)

GACU:

117548138(pparg)

EMAC:

134882560(pparg)

ELY:	117257221(pparg)

EFO:	125892831(pparg)

PLEP:

121957686(pparg)

SLUC:

116051327(pparg)

ECRA:

117943530(pparg)

ESP:	116687875(pparg)

PFLV:

114554582(pparg)

GAT:	120835430(pparg)

PPUG:

119229736(pparg)

AFB:	129106394(pparg)

CLUM:

117730250(pparg)

PSWI:

130209002(pparg)

CANA:

137795926(pparg)

CVE:	137873853(pparg)

MSAM:

119885690(pparg)

SCHU:

122887596(pparg)

CUD:	121506534(pparg)

SPUL:

138605355(pparg)

LMIX:

132978110(pparg)

ALAT:

119021008(pparg)

ASTR:

137595128(pparg)

MZE:	101485991(pparg)

ONL:	100711231(pparg)

OAU:	116313637(pparg)

OLA:	100304459(pparg)

OML:	112144662(pparg)

CSAI:

133448664(pparg)

XMA:	102229218(pparg)

XCO:	114136130(pparg)

XHE:	116711123(pparg)

PRET:

103464445(pparg)

PFOR:

103136305(pparg)

PLAI:

106954729(pparg)

PMEI:

106923766(pparg)

GAF:	122834758(pparg)

PPRL:

129358130(pparg)

CVG:	107087543(pparg)

CTUL:

119798399(pparg)

GMU:	124856811(pparg)

NFU:	107385283(pparg)

KMR:	108231651(pparg)

ALIM:

106513826(pparg)

NWH:	119411830(pparg)

AOCE:

111564578(pparg)

EJA:	138196287(pparg)

BFRE:

138616519(pparg)

MCEP:

125006753(pparg)

CSEM:

103385631(pparg)

POV:	109635570(pparg)

SSEN:

122768506(pparg)

SSOE:

131461143(pparg)

HHIP:

117760900(pparg)

HSP:	118105123(pparg)

PPLT:

128450015(pparg)

SMAU:

118309229(pparg)

LCF:

108890100

SDU:	111224020(pparg)

SLAL:

111658805 111667647 111670200(pparg)

XGL:	120807084(pparg)

HCQ:	109529222(pparg)

SSCV:

125977474(pparg)

SBIA:

133507121(pparg)

PEE:	133408284(pparg)

PTAO:

133483353(pparg)

BPEC:

110168463(pparg)

MALB:

109965555(pparg)

BSPL:

114856013(pparg)

SJO:	128354950(pparg)

SSCO:

133978082(pparg)

GMH:	115556951(pparg)

SASA:

100136393(pparg) 106566754 106583865 106583866

STRU:

115149901 115166142 115168395

OTW:	112215766 112221460 112255114(pparg)

OMY:	100505416 110492412 110528708(pparg)

OGO:	124023950(pparg) 124031699 124045680

ONE:	115102096 115120699 115131884

OKI:	109869769 109891477(pparg) 109907766

OKE:	118359629 118361398 118372504(pparg)

OMM:	135504660 135541253(pparg)

OCLA:

139368793 139413959 139416266

SALP:

111966207 112069430(pparg)

SNH:	120037108(pparg) 120059497 120061319

CCLU:

121538561 121545409 121560752

ELS:	105013043 105029138

SFM:	108929802(pparg)

PKI:	111837542(pparg)

AANG:

118210670(pparg)

AROT:

135238525(pparg)

CCOG:

133109533(pparg)

LOC:	102692076(pparg)

PSPA:

121297981 121328698

ARUT:

117412001 117413933

PSEX:

120540275(pparg)

LCM:	102360245(PPARG)

CMK:	103185017(pparg)

RTP:	109911575(pparg)

CPLA:

122558958(pparg)

HOC:	132822309(pparg)

LERI:

129704847(pparg)

PMRN:

103091849 116947501 116949271 116951213

LRJ:	133342505 133342738 133350674 133351590(PPARD) 133356535 133356713

BFO:

BBEL:

SPU:

LPIC:

APLC:

ARUN:

AAMU:

SKO:

PFLL:

AGRG:

DVV:

CCRN:

HVI:

MQU:

DFR:

LGI:	LOTGIDRAFT_238472

PVUL:

PCAN:

LSAX:

BGT:

HRF:	124138185 124140499

HRJ:	124264112 124268679

HASI:

137261366

CRG:	105317849 105322741

CANU:

128164853 128193245

CVN:	111123084 111126890

OED:

125645785

MYI:

110455413

PMAX:

117317926 117318076 117339313

AIRR:

138310296 138330042 138335740

MMER:

RPHI:

DPOL:

MAEA:

LJP:	135464584 135466352

» show all

Reference

PMID:9065481

Authors

Mukherjee R, Jow L, Croston GE, Paterniti JR Jr

Title

Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists.

Journal

J Biol Chem 272:8071-6 (1997)
DOI:10.1074/jbc.272.12.8071

Sequence

[hsa:5468]

Reference

PMID:19883731

Authors

Eberhardt NL, Grebe SK, McIver B, Reddi HV

Title

The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer.

Journal

Mol Cell Endocrinol 321:50-6 (2010)
DOI:10.1016/j.mce.2009.10.013

Reference

PMID:20829347

Authors

Park SH, Choi HJ, Yang H, Do KH, Kim J, Lee DW, Moon Y

Title

Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.

Journal

J Biol Chem 285:35330-9 (2010)
DOI:10.1074/jbc.M110.136259

Sequence

[hsa:5468]

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