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Melanokortin

Izvor: Wikipedija
Derivati pro-opiomelanokortina
POMC
     
γ-MSH ACTH β-lipotropin
         
  α-MSH CLIP γ-lipotropin β-endorfin
       
    β-MSH  

Melanokortini su grupa peptidnih hormona u koje se ubrajaju adrenokortikotropski hormon (ACTH) i razne forme melanocit-stimulišućeg hormona (MSH).[1] Oni mogu biti sintetički (kreirani u laboratoriji) ili endogeno proizvedeni iz proopiomelanokortina (POMC) u pituitarnoj žlezdi.[2] Melanokortini dejstvuju putem vezivanja za i aktiviranja melanokortinskog receptora.

Literatura

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  1. Gantz I, Fong TM (March 2003). „The melanocortin system”. Am. J. Physiol. Endocrinol. Metab. 284 (3): E468–74. DOI:10.1152/ajpendo.00434.2002. PMID 12556347. Arhivirano iz originala na datum 2009-02-26. Pristupljeno 2014-04-21. 
  2. Raffin-Sanson ML, de Keyzer Y, Bertagna X (August 2003). „Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions”. Eur. J. Endocrinol. 149 (2): 79–90. PMID 12887283. 

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