NFKB2

NFKB2

A gene on chromosome 10q24 that encodes a kappa light polypeptide of NF-kappaB (nuclear factor-kappaB), a rapidly acting primary transcription factor which is found in all cell types and involved in cellular responses to stimuli, including cytokines and stress. NF-kappaB plays a key role in regulating the immune response to infection; it is involved in various biological processes including inflammation, immunity, differentiation, cell growth, tumourigenesis and apoptosis.
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Our results show that IRF9, STAT2, and NFKB2 are important TFs during the progression of DN.
Identification of Transcription Regulatory Relationships in Diabetic Nephropathy
Defects in the transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), inducible costimulator (ICOS), B-cell-activating factor receptor (BAFF-R), and nuclear factor kappa B subunit 2 (NFKB2) genes have been identified in some patients with CVID [1, 6, 7].
Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency
Effects of MEKT1 on mRNA Expression of Nur77, Nurr1, NeuroD1, Tpit, Pitx, NFkB1, and NFkB2. We next examined the effect of MEKT1 on mouse Nur77, Nurr1, NeuroD1, Tpit, Pitx, NFkB1, and NFkB2 mRNA expression in AtT20 cells.
Inhibitory Effects of a Novel PPAR-[gamma] Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells
coli had a greater response to the bacterial challenge via up-regulation of genes associated with 'acute phase response signaling', i.e., interleukin-6 (IL6) and nuclear factor NF-kappa-B p100 subunit (NFKB2), than cows with high-susceptibility to mastitis (Brand et al., 2011).
Systematic and Integrated Analysis Approach to Prioritize Mastitis Resistant Genes
Target gene expression for Pprc1 (Q6NZN1), Nrf1, Nrf2, Btrc (Q3ULA2) and Nfkb2 (Q9WTK5) was measured with FAM (6-carboxyfluorescein) reporter dye-labeled probes (see Table S5).
Genome-wide association study to identify genes related to renal mercury concentrations in mice
The major form of NF-[kappa]B is a heterodimer of the p50 and p65/RelA subunits which are encoded by the NFKB1 and NFKB2 genes, respectively [4].
Association between NFKB1-94ins/del ATTG promoter polymorphism and cancer susceptibility: an updated meta-analysis
We selected six genes in the DLBCL data, which are SPIB, IRF8, NFKB2, LMO2, FCGRT, and BCL7B.
A robust hybrid approach based on estimation of distribution algorithm and support vector machine for hunting candidate disease genes
hydronephrosis Imipramine ADRA18, ADRA1D Renal nephritis Imipramine TP53, NOS1, CTNS, ALB, NFKB2, VDR, PDE4D, PPP3CA, ACE Heart failure lmipramine EPO, NOS1, ATP1A3, CACNA1D, ACCN3, KCNG2, PDE4D, SLC9A1, TTN, ADRB3, KCNJ11, ADRA1D.
Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine
The other downregulated genes found in these patients were MTOR, NFKB2, and IL12RB2 (Table 3).
Cysticerci drive dendritic cells to promote in vitro and in vivo Tregs differentiation
Five members of the NFkB family have been identified: NFkB1 (p50/pl05), NFkB2 (p52/pl00), RelA (p65), RelB, and c-Rel.
Phosphorylation of p65 is required for zinc oxide nanoparticle-induced interleukin 8 expression in human bronchial epithelial cells

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