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KIF2A

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KIF2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKIF2A, CDCBM3, HK2, KIF2, kinesin heavy chain member 2A, kinesin family member 2A
External IDsOMIM: 602591; MGI: 108390; HomoloGene: 3320; GeneCards: KIF2A; OMA:KIF2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004520
NM_001098511
NM_001243952
NM_001243953

RefSeq (protein)

NP_001091981
NP_001230881
NP_001230882
NP_004511

Location (UCSC)Chr 5: 62.31 – 62.39 MbChr 13: 107.1 – 107.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.[5][6] In mice, KIF2A is essential for proper neurogenesis and deficiency of KIF2A in mature neurons results in the loss of those neurons.[7]

Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM][6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000068796Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021693Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D (May 1997). "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique". Genomics. 42 (1): 67–73. doi:10.1006/geno.1997.4720. PMID 9177777.
  6. ^ a b "Entrez Gene: KIF2A kinesin heavy chain member 2A".
  7. ^ Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, et al. (November 2022). "KIF2A deficiency causes early-onset neurodegeneration". Proceedings of the National Academy of Sciences of the United States of America. 119 (46): e2209714119. Bibcode:2022PNAS..11909714R. doi:10.1073/pnas.2209714119. PMC 9674219. PMID 36343267.

Further reading

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[edit]
  • Overview of all the structural information available in the PDB for UniProt: O00139 (Human Kinesin-like protein KIF2A) at the PDBe-KB.


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