ERG11

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Structures	Swiss-model
Domains	InterPro

Sterol 14-demethylase
Sterol 14-demethylase
Identifiers
Organism	Saccharomyces cerevisiae
Symbol	ERG11
Alt. symbols	CYP51F1
Entrez	856398
HomoloGene	55488
RefSeq (mRNA)	NM_001179137
RefSeq (Prot)	NP_011871
UniProt	P10614
Other data
EC number	1.14.14.154
Chromosome	VIII: 0.12 - 0.12 Mb
Structures
Search for
Structures	Swiss-model
Domains	InterPro

ERG11 or Sterol 14-demethylase is a fungal cytochrome P450 enzyme originally from Saccharomyces cerevisiae, belongs to family CYP51, with the CYP Symbol CYP51F1.^[1] ERG11 catalyzes the C14-demethylation of lanosterol to 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol which is the first step of biosynthesis of the zymosterol, zymosterol will be further converted into Ergosterol.^[2]

References

^ Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. (October 2003). "Global analysis of protein expression in yeast". Nature. 425 (6959): 737–41. Bibcode:2003Natur.425..737G. doi:10.1038/nature02046. PMID 14562106. S2CID 4344864.
^ Mo C, Bard M (September 2005). "Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex". Journal of Lipid Research. 46 (9): 1991–8. doi:10.1194/jlr.M500153-JLR200. PMID 15995173.

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[1] Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. (October 2003). "Global analysis of protein expression in yeast". Nature. 425 (6959): 737–41. Bibcode:2003Natur.425..737G. doi:10.1038/nature02046. PMID 14562106. S2CID 4344864.

[2] Mo C, Bard M (September 2005). "Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex". Journal of Lipid Research. 46 (9): 1991–8. doi:10.1194/jlr.M500153-JLR200. PMID 15995173.

[1]

[2]

v t e Cytochromes, oxygenases: cytochrome P450 (Most belong to EC 1.14)
CYP1	A1 A2 A5 B1
CYP2	A6 A7 A13 B6 C8 C9 C18 C19 D6 E1 F1 J2 R1 S1 U1 W1
CYP3 (CYP3A)	A4 A5 A7 A37 A43
CYP4	A11 A22 B1 F2 F3 F8 F11 F12 F22 V2 X1 Z1
CYP5-20	CYP5 (A1) CYP6 (G1, M2) CYP7 (A1, B1) CYP8 (A1, B1) CYP9 CYP10 CYP11 (A1, A2, B1, B2, B3, C1) CYP12 CYP13 CYP14 CYP15 CYP16 CYP17 (A1) CYP18 CYP19 (A1) CYP20 (A1)
CYP21-49	CYP21 (A2) CYP22 (A1) CYP23 CYP24 (A1) CYP25 CYP26 (A1, B1, C1) CYP27 (A1, B1, C1) CYP28 (A1) CYP29 CYP35 (B1) CYP39 (A1) CYP46 (A1)
CYP51-69	CYP51 (A1, F1) CYP52 CYP53 A1 CYP55 A1 CYP56 A1 CYP61
CYP71-99	CYP71 (C1, C2, C3, C4, Z6, AJ4, AV1, BA1) CYP72A1 CYP73A1 CYP74 (D1) CYP75 (A1, B1) CYP76 (B6, M7) CYP79 (A1, A2, B1, B2, B3, D1, D2, D3, D4) CYP80 (A1, B1, G2) CYP81 (E1, E3, E7, E9) CYP88D6 CYP90C1 CYP93E1 CYP97C1 CYP99A3
CYP101-281	CYP101A1 CYP102A1 CYP105 A1 D7 CYP106A2 CYP107 A1 G1 CYP109 B1 E1 CYP111 CYP113A1 CYP119A1 CYP123 CYP125A1 CYP139 CYP147 CYP152 A1 B1 CYP154C3 CYP158A CYP161C CYP170 A1 B1 CYP176A1 CYP183A CYP197 CYP199A2 CYP255A
CYP301-499	CYP303A1 CYP305 M2 Halloween genes ( CYP302A1, CYP306A1, CYP307A1, CYP307A2, CYP314A1, CYP315A1) CYP318A1
CYP501-699	CYP503 CYP504B1
CYP701-999	CYP704B22 CYP710 CYP720A1

References

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