Alprazolam triazolobenzophenone
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| Formula | C17H15ClN4O |
| Molar mass | 326.78 g·mol−1 |
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Alprazolam triazolobenzophenone is a chemical compound that is a prodrug for the benzodiazepine derivative alprazolam. At neutral pH it readily cyclizes to alprazolam, while in acidic conditions alprazolam undergoes a ring-opening reaction back to the ketone. A series of related acyl derivatives was researched in the 1980s as injectable water-soluble prodrugs of alprazolam,[1] but were never developed for medical use. Subsequently, this compound has been detected as a designer drug, first being identified from a seizure in Spain in March 2014.[2]
See also
[edit]References
[edit]- ^ Cho MJ, Sethy VH, Haynes LC (August 1986). "Sequentially labile water-soluble prodrugs of alprazolam". Journal of Medicinal Chemistry. 29 (8): 1346–50. doi:10.1021/jm00158a004. PMID 3016261.
- ^ "Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines" (PDF). Advisory Council on the Misuse of Drugs. April 2020.
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