SMAP1

Stromal membrane-associated protein 1 is a protein that in humans is encoded by the SMAP1 gene.

SMAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRR
Identifiers
Aliases	SMAP1, SMAP-1, small ArfGAP 1
External IDs	OMIM: 611372; MGI: 2138261; HomoloGene: 134676; GeneCards: SMAP1; OMA:SMAP1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q13 Start 70,667,776 bp End 70,862,011 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 A5 Start 23,883,927 bp End 23,961,398 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of sigmoid colon oral cavity Pons mucosa of pharynx duodenum skin of thigh skin of hip islet of Langerhans ganglionic eminence Top expressed in blood genital tubercle tail of embryo seminiferous tubule spermatid dentate gyrus of hippocampal formation granule cell neural layer of retina superior frontal gyrus calvaria gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin binding metal ion binding GTPase activator activity Cellular component cytoplasm plasma membrane membrane Biological process positive regulation of GTPase activity regulation of clathrin-dependent endocytosis positive regulation of erythrocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60682 98366 Ensembl ENSG00000112305 ENSMUSG00000026155 UniProt Q8IYB5 Q91VZ6 RefSeq (mRNA) NM_001044305 NM_001281439 NM_001281440 NM_021940 NM_001290683 NM_028534 NM_001357395 RefSeq (protein) NP_001037770 NP_001268368 NP_001268369 NP_068759 NP_001277612 NP_082810 NP_001344324 Location (UCSC) Chr 6: 70.67 – 70.86 Mb Chr 1: 23.88 – 23.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tanabe K, Torii T, Natsume W, et al. (2005). "A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis". Mol. Biol. Cell. 16 (4): 1617–28. doi:10.1091/mbc.E04-08-0683. PMC 1073646. PMID 15659652.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Barragan I, Marcos I, Borrego S, Antiñolo G (2006). "Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa". Int. J. Mol. Med. 16 (6): 1163–7. doi:10.3892/ijmm.16.6.1163. PMID 16273301.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.