Wolfgang Karl "Bill" Joklik (November 16, 1926 – July 7, 2019) was a virologist and James B. Duke Professor Emeritus of Molecular Genetics and Microbiology at Duke University, from which he retired in 1993 after 25 years chairing the department. In 1981, he founded the American Society for Virology, the first scientific society specifically for virologists, and served a two-year term as its founding president. In the same year, he was elected to the United States National Academy of Sciences. He has been described as "one of the earliest molecular virologists" and is best known for his research on poxviruses and reoviruses, and for work on interferon proteins.