John Wayles (January 31, 1715 – May 28, 1773) was a colonial American planter, slave trader and lawyer in colonial Virginia. He is historically best known as the father-in-law of Thomas Jefferson, the third President of the United States. Wayles married three times, with these marriages producing eleven children; only five of them lived to adulthood. Wayles' continual rapes of slave Betty Hemings resulted in six additional children, including Sally Hemings, who was the mother of six children by Thomas Jefferson and half-sister of Martha Jefferson.