| dbo:abstract
|
- Inhibiční motiv imunoreceptorů na bázi tyrosinu (Immunoreceptor tyrosine-based inhibitory motif, ITIM) je konzervovaná sekvence aminokyselin, která se nachází intracelulárně v cytoplazmatických doménách mnoha inhibičních receptorů rodiny nekatalytických tyrosin-fosforylovaných receptorů nacházejících se na imunitních buňkách. Tyto imunitní buňky zahrnují T buňky, B buňky, NK buňky, dendritické buňky, makrofágy a žírné buňky. ITIM motivy reagují s fosfatázami obsahujícími doménu SH2, které inhibují buněčnou aktivaci. Receptory nesoucí ITIM mají důležitou roli v negativní regulaci na různých úrovních imunitní odpovědi. Seznam lidských kandidátských proteinů obsahujících ITIM byl vytvořen skenováním celého proteomu. Zahrnuje více než 135 proteinů s motivem ITIM. Tento seznam je dále rozšířen studiem vzácných lidských SNP, které vytvářejí konsensuální sekvenci S / I / V / LxYxxI / V / L. (cs)
- An immunoreceptor tyrosine-based inhibitory motif (ITIM), is a conserved sequence of amino acids that is found intracellularly in the cytoplasmic domains of many inhibitory receptors of the non-catalytic tyrosine-phosphorylated receptor family found on immune cells. These immune cells include T cells, B cells, NK cells, dendritic cells, macrophages and mast cells. ITIMs have similar structures of S/I/V/LxYxxI/V/L, where x is any amino acid, Y is a tyrosine residue that can be phosphorylated, S is the amino acide Serine, I is the amino acid Isoleucine, and V is the amino acid Valine. ITIMs recruit SH2 domain-containing phosphatases, which inhibit cellular activation. ITIM-containing receptors often serve to target Immunoreceptor tyrosine-based activation motif(ITAM)-containing receptors, resulting in an innate inhibition mechanism within cells. ITIM bearing receptors have important role in regulation of immune system allowing negative regulation at different levels of the immune response. A list of human candidate ITIM-containing proteins has been generated by proteome-wide scans. It has included more than 135 proteins with ITIM motif. This list is reportedly expanded by studying rare human SNPs that create the consensus signature S/I/V/LxYxxI/V/L motif. (en)
- I motivi ITIM (acronimo inglese di Immunoreceptor Tyrosine-based Inhibition Motif) sono delle sequenze di amminoacidi (S/I/V/LxYxxI/V/L) che si trovano nell'estremità citoplasmatica di molti recettori inibitori del sistema immunitario. Quando i recettori inibitori che contengono questi motivi interagiscono con il loro ligando i motivi ITIM vengono fosforilati da enzimi appartenenti alla famiglia delle protein chinasi src e questo permette il reclutamento di altri enzimi come fosfotirosina e fosfatasi che diminuiscono l'attivazione di molecole coinvolte nella segnalazione cellulare. Gli antagonisti si chiamano profili ITAM. (it)
- 免疫受体酪氨酸抑制基序（英語：Immunoreceptor tyrosine-based inhibitory motif，缩写ITIM）是一个保守的氨基酸序列（S/I/V/LxYxxI/V/L）位于许多免疫系统抑制受体的末端细胞质区域。在带有ITIM的受体与其对应的配体结合后，ITIM会发生酪氨酸磷酸化（通常由激酶家族进行催化），允许他们招募其他酶如磷酸化酪氨酸磷酸酶（如、或者磷酸肌醇磷酸酶）。这些磷酸酶会参与下游细胞信号分子的去磷酸化作用。人类的所有带ITIM的蛋白都已通过全基因组分析鉴定出来。 (zh)
|
| dbo:wikiPageID
| |
| dbo:wikiPageLength
|
- 15621 (xsd:nonNegativeInteger)
|
| dbo:wikiPageRevisionID
| |
| dbo:wikiPageWikiLink
| |
| dbp:wikiPageUsesTemplate
| |
| dcterms:subject
| |
| gold:hypernym
| |
| rdfs:comment
|
- I motivi ITIM (acronimo inglese di Immunoreceptor Tyrosine-based Inhibition Motif) sono delle sequenze di amminoacidi (S/I/V/LxYxxI/V/L) che si trovano nell'estremità citoplasmatica di molti recettori inibitori del sistema immunitario. Quando i recettori inibitori che contengono questi motivi interagiscono con il loro ligando i motivi ITIM vengono fosforilati da enzimi appartenenti alla famiglia delle protein chinasi src e questo permette il reclutamento di altri enzimi come fosfotirosina e fosfatasi che diminuiscono l'attivazione di molecole coinvolte nella segnalazione cellulare. Gli antagonisti si chiamano profili ITAM. (it)
- 免疫受体酪氨酸抑制基序（英語：Immunoreceptor tyrosine-based inhibitory motif，缩写ITIM）是一个保守的氨基酸序列（S/I/V/LxYxxI/V/L）位于许多免疫系统抑制受体的末端细胞质区域。在带有ITIM的受体与其对应的配体结合后，ITIM会发生酪氨酸磷酸化（通常由激酶家族进行催化），允许他们招募其他酶如磷酸化酪氨酸磷酸酶（如、或者磷酸肌醇磷酸酶）。这些磷酸酶会参与下游细胞信号分子的去磷酸化作用。人类的所有带ITIM的蛋白都已通过全基因组分析鉴定出来。 (zh)
- Inhibiční motiv imunoreceptorů na bázi tyrosinu (Immunoreceptor tyrosine-based inhibitory motif, ITIM) je konzervovaná sekvence aminokyselin, která se nachází intracelulárně v cytoplazmatických doménách mnoha inhibičních receptorů rodiny nekatalytických tyrosin-fosforylovaných receptorů nacházejících se na imunitních buňkách. Tyto imunitní buňky zahrnují T buňky, B buňky, NK buňky, dendritické buňky, makrofágy a žírné buňky. ITIM motivy reagují s fosfatázami obsahujícími doménu SH2, které inhibují buněčnou aktivaci. Receptory nesoucí ITIM mají důležitou roli v negativní regulaci na různých úrovních imunitní odpovědi. (cs)
- An immunoreceptor tyrosine-based inhibitory motif (ITIM), is a conserved sequence of amino acids that is found intracellularly in the cytoplasmic domains of many inhibitory receptors of the non-catalytic tyrosine-phosphorylated receptor family found on immune cells. These immune cells include T cells, B cells, NK cells, dendritic cells, macrophages and mast cells. ITIMs have similar structures of S/I/V/LxYxxI/V/L, where x is any amino acid, Y is a tyrosine residue that can be phosphorylated, S is the amino acide Serine, I is the amino acid Isoleucine, and V is the amino acid Valine. ITIMs recruit SH2 domain-containing phosphatases, which inhibit cellular activation. ITIM-containing receptors often serve to target Immunoreceptor tyrosine-based activation motif(ITAM)-containing receptors, r (en)
|
| rdfs:label
|
- ITIM (cs)
- Immunoreceptor tyrosine-based inhibitory motif (en)
- ITIM (it)
- 免疫受体酪氨酸抑制基序 (zh)
|
| owl:sameAs
| |
| prov:wasDerivedFrom
| |
| foaf:isPrimaryTopicOf
| |
| is dbo:wikiPageDisambiguates
of | |
| is dbo:wikiPageWikiLink
of | |
| is foaf:primaryTopic
of | |
