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In molecular biology, a downstream promoter element (DPE) is a core promoter element. Like all core promoters, the DPE plays an important role in the initiation of gene transcription by RNA polymerase II. The DPE was first described by T. W. Burke and James T. Kadonaga in Drosophila melanogaster at the University of California, San Diego in 1996. It is also present in other species including humans, but not Saccharomyces cerevisiae.

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  • Downstream Promoter Element (engl., zu deutsch etwa ‚strangabwärtiges Promotorelement‘, DPE) ist ein Bereich eines Promotors und die Bindungsstelle für den Transkriptionsfaktor TFIID. (de)
  • In molecular biology, a downstream promoter element (DPE) is a core promoter element. Like all core promoters, the DPE plays an important role in the initiation of gene transcription by RNA polymerase II. The DPE was first described by T. W. Burke and James T. Kadonaga in Drosophila melanogaster at the University of California, San Diego in 1996. It is also present in other species including humans, but not Saccharomyces cerevisiae. Together with the initiator motif (Inr), another core promoter element, the DPE is recognized by the transcription factor II D (TFIID) subunits TAF6 and TAF9. It has been shown that DPE-dependent basal transcription depends highly on the Inr (and vice versa) and on correct spacing between the two elements. The DPE consensus sequence was originally thought to be RGWCGTG, however more recent studies have suggested it to be the similar but more general sequence RGWYV(T). It is located about 28–33 nucleotides downstream of the transcription start site. (en)
  • En genética molecular de eucariotas se define promotor mínimo (en inglés, core promoter) como la mínima secuencia de ADN en dirección 5' de un gen que es suficiente para iniciar la transcripción de este mediante la maquinaria asociada a la ARN polimerasa II.​​ Se trata de una estructura compleja, con elementos discretos que son reconocidos por varios factores generales de transcripción de forma específica, de modo que permite el ensamblaje de una superestructura, casi una estructura cuaternaria, de variadas proteínas, que incluyen tanto a dichos factores generales de transcripción como a otros elementos, que finalmente permiten la actividad de la ARN polimerasa II y, por ello, la transcripción del gen situado en el extremo 3' del promotor.​ (es)
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  • Downstream Promoter Element (engl., zu deutsch etwa ‚strangabwärtiges Promotorelement‘, DPE) ist ein Bereich eines Promotors und die Bindungsstelle für den Transkriptionsfaktor TFIID. (de)
  • En genética molecular de eucariotas se define promotor mínimo (en inglés, core promoter) como la mínima secuencia de ADN en dirección 5' de un gen que es suficiente para iniciar la transcripción de este mediante la maquinaria asociada a la ARN polimerasa II.​​ Se trata de una estructura compleja, con elementos discretos que son reconocidos por varios factores generales de transcripción de forma específica, de modo que permite el ensamblaje de una superestructura, casi una estructura cuaternaria, de variadas proteínas, que incluyen tanto a dichos factores generales de transcripción como a otros elementos, que finalmente permiten la actividad de la ARN polimerasa II y, por ello, la transcripción del gen situado en el extremo 3' del promotor.​ (es)
  • In molecular biology, a downstream promoter element (DPE) is a core promoter element. Like all core promoters, the DPE plays an important role in the initiation of gene transcription by RNA polymerase II. The DPE was first described by T. W. Burke and James T. Kadonaga in Drosophila melanogaster at the University of California, San Diego in 1996. It is also present in other species including humans, but not Saccharomyces cerevisiae. (en)
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  • Downstream Promoter Element (de)
  • Promotor mínimo (es)
  • Downstream promoter element (en)
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