About: Chemoaffinity hypothesis

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The Chemoaffinity hypothesis states that neurons make connections with their targets based on interactions with specific molecular markers and, therefore, that the initial wiring diagram of an organism is (indirectly) determined by its genotype. The markers are generated during cellular differentiation and aid not only with synaptogenesis, but also act as guidance cues for their respective axon.

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  • The Chemoaffinity hypothesis states that neurons make connections with their targets based on interactions with specific molecular markers and, therefore, that the initial wiring diagram of an organism is (indirectly) determined by its genotype. The markers are generated during cellular differentiation and aid not only with synaptogenesis, but also act as guidance cues for their respective axon. (en)
  • A Hipótese de Quimioafinidade propõe que axônios reconhecem as células, ou grupo de células, com as quais farão sinapse (alvos) por meio de marcadores moleculares específicos. Esse reconhecimento seletivo é a base para a formação de uma rede funcional de conexões neuronais. Durante a diferenciação celular, as células às quais os axônios irão se conectar produzem esses sinais, que não apenas os guiam, mas também auxiliam no processo de sinaptogênese. (pt)
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  • The Chemoaffinity hypothesis states that neurons make connections with their targets based on interactions with specific molecular markers and, therefore, that the initial wiring diagram of an organism is (indirectly) determined by its genotype. The markers are generated during cellular differentiation and aid not only with synaptogenesis, but also act as guidance cues for their respective axon. (en)
  • A Hipótese de Quimioafinidade propõe que axônios reconhecem as células, ou grupo de células, com as quais farão sinapse (alvos) por meio de marcadores moleculares específicos. Esse reconhecimento seletivo é a base para a formação de uma rede funcional de conexões neuronais. Durante a diferenciação celular, as células às quais os axônios irão se conectar produzem esses sinais, que não apenas os guiam, mas também auxiliam no processo de sinaptogênese. (pt)
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  • Chemoaffinity hypothesis (en)
  • Hipótese de Quimioafinidade (pt)
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