Espiritu Santo Parish, now known as the Archdiocesan Shrine of Espiritu Santo, is a Roman Catholic parish belonging to the Archdiocese of Manila that is located at 1912 Rizal Avenue corner Tayuman Street, Santa Cruz, Manila, Philippines. It was declared an Archdiocesan Shrine by Manila Archbishop Emeritus Luis Antonio G. Cardinal Tagle on June 8, 2014, the Solemnity of the Pentecost. Rev. Msgr. Eymard Dennis Peter Marcelino S. Odiver, PC is the newly appointed parish priest and rector of the church, succeeding Rev. Fr. Wilmer R. Rosario, JCD, who has been its parish priest from 2015 to 2022.