| dbo:abstract
|
- The enzyme 4-hydroxybenzoate 3-monooxygenase, also commonly referred to as para-hydroxybenzoate hydroxylase (PHBH), is a flavoprotein belonging to the family of oxidoreductases. Specifically, it is a hydroxylase, and is one of the most studied enzymes and catalyzes reactions involved in soil detoxification, metabolism, and other biosynthetic processes. 4-hydroxybenzoate 3-monooygenase catalyzes the regioselective hydroxylation of 4-hydroxybenzoate, giving 3,4-dihydroxybenzoate as the product. The mechanism consists of the following general steps: (1) reduction of the flavin, (2) reaction of the flavin with O2, producing C4a-hydroperoxyflavin, and (3) binding and activation of the substrate, leading to product formation and release. Throughout the mechanism, the flavin changes between “open” and “closed” conformations, thus altering the substrate reaction environment. The open conformation allows solvent access to the active site; the enzyme adopts this conformation for substrate binding and product release. A closed conformation isolates the reaction from solvent, which helps to stabilize the reaction intermediates. (en)
- La 4-idrossibenzoato 3-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 4-idrossibenzoato + NADPH + H+ + O2 ⇄ protocatecuato + NADP+ + H2O L'enzima è una flavoproteina (FAD). La maggior parte degli enzimi di Pseudomonas sono altamente specifici per il NADPH. (cf. la 4-idrossibenzoato 3-monoossigenasi (NAD(P)H) (numero EC 1.14.13.33). (it)
- 4-ヒドロキシ安息香酸-3-モノオキシゲナーゼ（4-hydroxybenzoate 3-monooxygenase）は、次の化学反応を触媒する酸化還元酵素である。 4-ヒドロキシ安息香酸 + NADPH + H+ + O2 プロトカテク酸 + NADP+ + H2O 反応式の通り、この酵素の基質は4-ヒドロキシ安息香酸とNADPHとH+とO2、生成物はプロトカテク酸とNADP+とH2Oである。補酵素としてFADを用いる。 組織名は4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)で、別名にp-hydroxybenzoate hydrolyase、p-hydroxybenzoate hydroxylase、4-hydroxybenzoate 3-hydroxylase、4-hydroxybenzoate monooxygenase、4-hydroxybenzoic hydroxylase、p-hydroxybenzoate-3-hydroxylase、p-hydroxybenzoic acid hydrolase、p-hydroxybenzoic acid hydroxylase、p-hydroxybenzoic hydroxylaseがある。 (ja)
|
| dbo:ecNumber
| |
| dbo:thumbnail
| |
| dbo:wikiPageID
| |
| dbo:wikiPageLength
|
- 9528 (xsd:nonNegativeInteger)
|
| dbo:wikiPageRevisionID
| |
| dbo:wikiPageWikiLink
| |
| dbp:caption
|
- Crystal structure of 4-hydroxybenzoate 3-monooxygenase (en)
|
| dbp:casNumber
| |
| dbp:ecNumber
| |
| dbp:goCode
| |
| dbp:iubmbEcNumber
| |
| dbp:name
| |
| dbp:wikiPageUsesTemplate
| |
| dcterms:subject
| |
| rdf:type
| |
| rdfs:comment
|
- La 4-idrossibenzoato 3-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 4-idrossibenzoato + NADPH + H+ + O2 ⇄ protocatecuato + NADP+ + H2O L'enzima è una flavoproteina (FAD). La maggior parte degli enzimi di Pseudomonas sono altamente specifici per il NADPH. (cf. la 4-idrossibenzoato 3-monoossigenasi (NAD(P)H) (numero EC 1.14.13.33). (it)
- 4-ヒドロキシ安息香酸-3-モノオキシゲナーゼ（4-hydroxybenzoate 3-monooxygenase）は、次の化学反応を触媒する酸化還元酵素である。 4-ヒドロキシ安息香酸 + NADPH + H+ + O2 プロトカテク酸 + NADP+ + H2O 反応式の通り、この酵素の基質は4-ヒドロキシ安息香酸とNADPHとH+とO2、生成物はプロトカテク酸とNADP+とH2Oである。補酵素としてFADを用いる。 組織名は4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)で、別名にp-hydroxybenzoate hydrolyase、p-hydroxybenzoate hydroxylase、4-hydroxybenzoate 3-hydroxylase、4-hydroxybenzoate monooxygenase、4-hydroxybenzoic hydroxylase、p-hydroxybenzoate-3-hydroxylase、p-hydroxybenzoic acid hydrolase、p-hydroxybenzoic acid hydroxylase、p-hydroxybenzoic hydroxylaseがある。 (ja)
- The enzyme 4-hydroxybenzoate 3-monooxygenase, also commonly referred to as para-hydroxybenzoate hydroxylase (PHBH), is a flavoprotein belonging to the family of oxidoreductases. Specifically, it is a hydroxylase, and is one of the most studied enzymes and catalyzes reactions involved in soil detoxification, metabolism, and other biosynthetic processes. (en)
|
| rdfs:label
|
- 4-hydroxybenzoate 3-monooxygenase (en)
- 4-idrossibenzoato 3-monoossigenasi (it)
- 4-ヒドロキシ安息香酸-3-モノオキシゲナーゼ (ja)
|
| owl:sameAs
| |
| prov:wasDerivedFrom
| |
| foaf:depiction
| |
| foaf:isPrimaryTopicOf
| |
| foaf:name
|
- 4-hydroxybenzoate 3-monooxygenase (en)
|
| is dbo:wikiPageRedirects
of | |
| is dbo:wikiPageWikiLink
of | |
| is foaf:primaryTopic
of | |
