About: 18-Hydroxy-11-deoxycorticosterone

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18-Hydroxy-11-deoxycorticosterone (also known as 18-OH-DOC, 18,21-dihydroxyprogesterone, and 18,21-dihydroxypregn-4-ene-3,20-dione) is an endogenous steroid and a mineralocorticoid. It is a hydroxylated metabolite of 11-deoxycorticosterone. In rats, conversion of 11-deoxycorticosterone into 18-OH-DOC is catalyzed by the CYP11B3 enzyme.

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  • 18-Hydroxy-11-deoxycorticosterone (also known as 18-OH-DOC, 18,21-dihydroxyprogesterone, and 18,21-dihydroxypregn-4-ene-3,20-dione) is an endogenous steroid and a mineralocorticoid. It is a hydroxylated metabolite of 11-deoxycorticosterone. In rats, conversion of 11-deoxycorticosterone into 18-OH-DOC is catalyzed by the CYP11B3 enzyme. In humans, 18-OH-DOC is a weak mineralocorticoid. It may be increased in 17α-hydroxylase (CYP17A1) deficiency, in aldosterone synthase (CYP11B2) deficiency, in primary aldosteronism, and may also indicate a histologic variant of the aldosteronoma. Excessive secretion of 18-OH-DOC can cause mineralocorticoid excess syndrome, although these cases are very rare. (en)
  • 18-羟基-11-脱氧皮质酮（英語：18-Hydroxy-11-deoxycorticosterone，缩写18-OH-DOC）是CYP450酶CYP11B3催化11-脱氧皮质酮发生羟基化的产物，CYP11B3主要在大鼠新生儿的肾上腺表达。 (zh)
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  • 18,21-dihydroxy-4-pregnene-3,20-dione (en)
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  • (1S,3aS,3bR,9aR,9bS,11aR)-1-(Hydroxyacetyl)-11a-(hydroxymethyl)-9a-methyl-1,2,3,3a,3b,4,5,8,9,9a,9b,10,11,11a-tetradecahydro-7H-cyclopenta[a]phenanthren-7-one (en)
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  • 18-羟基-11-脱氧皮质酮（英語：18-Hydroxy-11-deoxycorticosterone，缩写18-OH-DOC）是CYP450酶CYP11B3催化11-脱氧皮质酮发生羟基化的产物，CYP11B3主要在大鼠新生儿的肾上腺表达。 (zh)
  • 18-Hydroxy-11-deoxycorticosterone (also known as 18-OH-DOC, 18,21-dihydroxyprogesterone, and 18,21-dihydroxypregn-4-ene-3,20-dione) is an endogenous steroid and a mineralocorticoid. It is a hydroxylated metabolite of 11-deoxycorticosterone. In rats, conversion of 11-deoxycorticosterone into 18-OH-DOC is catalyzed by the CYP11B3 enzyme. (en)
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  • 18-Hydroxy-11-deoxycorticosterone (en)
  • 18-羟基-11-脱氧皮质酮 (zh)
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