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Protein-coding gene in the species Homo sapiens
DIDO1 Identifiers Aliases DIDO1 External IDs OMIM : 604140 ; MGI : 1344352 ; HomoloGene : 34139 ; GeneCards : DIDO1 ; OMA :DIDO1 - orthologs RNA expression patternBgee Human Mouse (ortholog)Top expressed in buccal mucosa cell sural nerve right uterine tube tendon of biceps brachii body of uterus Achilles tendon olfactory zone of nasal mucosa left ovary popliteal artery tibial arteries
Top expressed in Paneth cell Rostral migratory stream atrioventricular valve maxillary prominence mandibular prominence ciliary body epithelium of lens medullary collecting duct primitive streak retinal pigment epithelium
More reference expression data
BioGPS
Wikidata
Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene .[ 5] [ 6]
Apoptosis , a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000101191 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038914 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP, Izpisua-Belmonte JC, Martinez-A C (Aug 1999). "DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development" . Proc Natl Acad Sci U S A . 96 (14): 7992–7. Bibcode :1999PNAS...96.7992G . doi :10.1073/pnas.96.14.7992 PMC 22175 PMID 10393935 . ^ a b "Entrez Gene: DIDO1 death inducer-obliterator 1" .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
