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The microbiota is a collective term for the micro-organisms that live in or on the human body. Specific clusters of microbiota are found on the skin or in the gastrointestinal tract, mouth, vagina and eyes.
The mechanism of gut microbiome and blood metabolites regulate the TME in multiple myeloma (MM) remain unclear. Here the authors show Lachnospiraceae can suppress MM cell phosphatidylcholine (PC) production, with the latter inhibiting CD8 T cell function via TP53 UFMylation elicited by exosomal SerpinB9 from multiple myeloma.
The microbiota is critical for metabolic health. Studies published in 2024 have revealed mechanisms by which key bacterial and micro-eukaryotic organisms optimize energy production in our body and ensure efficient metabolic function.
