(at around 39 mins) When Sandra Bullock was restrained and struggling in the hospital scene she really did cut herself by accident. So instead of using a body double for the injection, it really was Bullock who got the Tetanus shot in the scene.
The movie was shot in continuity, so Sandra Bullock had to meet with the crew every day so she could know what she knew on any given day.
The film was supposed to be shot in New Orleans, but Hurricane Katrina forced the filmmakers to choose another location.
Although they play mother and daughter in this movie, Kate Nelligan is only 14 years older than Sandra Bullock.
Shot in 45 days. DVD extras show scenes being filmed from late-February 2006 to 6 March 2006. It indicates the start of filming to be close to 19 January 2006.