One of the main reasons why the protagonists of the series are a rabbit and a dog are inspired by the classic rivalry that these two pets have in real life, because rabbits are prey for dogs.
Lola Boa and Gaspar are the characters in the series who can speak Spanish, both having a Latin American accent when speaking English.
Many speculated that Brandy and Mr. Whiskers had a romantic interest however they simply behaved like brothers until the final episode of the series "Rip Van Whiskers" where Brandy kisses him believing that he would die.
Unlike many Disney Channel animated series whose pilot is premiered on that channel to measure the interest of the audience, the pilot episode of Brandy and Mister Whiskey premiered at Disney Toon and later the series premiered on Disney Channel.
There is an episode of only 45 seconds long called "Ed vs. The Oyster" which is considered the shortest episode in the history of a Disney animated series.