- Is dyslexic and has combined type ADHD.
- Salma's paternal grandparents, Elias Hayek Labahi and Adela Dominguez, were both of Lebanese descent (Adela's family's surname was originally "Hid"). Salma's mother's family is of Mexican / Spanish descent.
- She was sent to a boarding school in Grand Coteau, Louisiana at age 12, but was soon sent back home after getting into trouble for frequently terrorizing the nuns.
- Frequently collaborates with Antonio Banderas and Robert Rodriguez, and is godmother to Rodriguez's children.
- Salma is an Arabic name that means "peace" or "calm".
- She and Francois Henri Pinault renewed their vows at Venice's Teatro La Fenice opera house in late April 2009 with 150 guests present. Among them were Penélope Cruz, Javier Bardem, Charlize Theron, Stuart Townsend, Woody Harrelson, Hayek's ex-boyfriend Edward Norton, French president Jacques Chirac, Lucy Liu, Ashley Judd, Antonio Banderas, Anna Wintour, Gael García Bernal, Diego Luna, Bono and Stella McCartney.
- She played a (mythological creature disguised as a) stripper twice: in From Dusk Till Dawn (1996) and in Dogma (1999) (a vampire and a muse respectively).
- As the announcer for the 2007 Academy Awards, she was able to announce her best friend Penélope Cruz' nominations for Best Actress for Volver (2006).
- She was considered for the role of Alicia Larde in A Beautiful Mind (2001). In real life, Alicia was from El Salvador. The character in the film was later changed to American-born, and given to Jennifer Connelly.
- Founded her own production company, Ventanarosa (1999). In July 2020, the production company signed a two-year first-look deal with HBO Max.
- Is the second Latin American actress to be nominated for the Best Actress in a Leading Role Academy Award, for her performance in Frida (2002). Brazilian veteran Fernanda Montenegro was the first, for Central Station (1998).
- Returned to work five months after giving birth to her daughter Valentina in order to begin filming Cirque du Freak: The Vampire's Assistant (2009).
- Studied drama at the Stella Adler Studio of Acting in New York City.
- Member of the jury at the Cannes Film Festival in 2005
- Donated $25,000 to a shelter in Coatzacoalcos for battered women. (February 2006)
- Her brother, Sami, designs custom chairs. His celebrity clients include Jennifer Aniston and her ex-husband, Brad Pitt.
- Her parents are Sami Hayek Dominguez (oil company executive) and Diana Jiménez Medina (opera singer).
- In 2004, Salma won a Daytime Emmy Award for Outstanding Directing in a Children/Youth/Family Special for The Maldonado Miracle (2003).
- In 2009, musician Prince included a song on his CD "Lotus Flow3r/MPLSound" that is about Salma Hayek. The song shares the same name as her daughter, Valentina.
- They called off their engagement in July 2008, but then after months of speculation about whether they were still a couple, Salma and Pinault married in a secret ceremony on Valentine's Day 2009 in the city hall of the Second Arrondissement in Paris.
- Chosen by People (USA) magazine as one of the 50 Most Beautiful People in the World in 1996, 2003 and 2008.
- Born on the same day as Keanu Reeves, they are two years apart.
- E! Entertainment voted her look at the 1997 Academy Awards one of the five most memorable in Oscar history. At the event, she wore a beaded Armani gown complemented by a 1920s diamond tiara.
- Studied international relations and drama at the Universidad Iberoamericana, a prestigious university in Mexico City, Mexico.
- Was named one of the ten most stylish women in the world by Mr. Blackwell (aka Richard Selzer) in 1997. InStyle named her the most stylish celebrity of 2003 and Eonline.com ranked her as the best dressed female celebrity.
- She was awarded a Star on the Hollywood Walk of Fame at 6901 Hollywood Boulevard in Hollywood, California on November 19, 2021. Adam Sandler and director Chloé Zhao were guest speakers at the ceremony. Her Walk of Fame star is located in front of the Chinese Theater Box Office.
- On March 9, 2007, she announced her engagement to François-Henri Pinault, chairman and chief executive officer of the luxury goods company PPR SA.
- She was considered for the role of the hacker Trinity in The Matrix (1999), which went to Carrie-Anne Moss.
- Was in attendance at the wedding of Reese Witherspoon to Jim Toth (26 March 2011).
- Salma fluently speaks Arabic, Spanish, Portuguese and English.
- Has appeared with Danny Trejo in five films: Desperado (1995), From Dusk Till Dawn (1996), Spy Kids 3: Game Over (2003), Once Upon a Time in Mexico (2003) and Muppets Most Wanted (2014).
- Visited Guatemala from 2 May 2005 to 5 May 2005 as ambassador to Youth/AIDS, to promote the prevention of the mortal disease. Ashley Judd and Colombian pop singer Juanes also came with her.
- Has three stepchildren with: François Pinault (born 1998), Mathilde Pinault (born 2001) and Augustin James Evangelista (born October 11, 2006) and one daughter: Valentina Paloma Pinault (born September 21, 2007) with husband François-Henri Pinault.
- Was ranked 8th of the 100 Sexiest Women by FHM Taiwan (2001).
- Won Best Newcomer at the 1989 Novela Awards for Un nuevo amanecer (1988).
- She was considered for the role of Alex Munday in Charlie's Angels (2000), which went to Lucy Liu.
- Ranked #31 in Stuff magazine's "102 Sexiest Women in the World" (2002).
- Named #34 on Maxim magazine's Hot 100 in 2005, then #90 in 2007. She was also ranked #12 in FHM magazine's "100 Sexiest Women in the World" in the 2005 special supplement , and then #36 the following year.
- She was considered for the role of Elektra Natchios in Daredevil (2003), which went to Jennifer Garner.
- She was considered for the role of Claire Wilson in Alvin and the Chipmunks (2007), which went to Cameron Richardson.
- Her spokeswoman is Jillian Roscoe.
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