IgE induces release of inflammatory mediators such as histamine and cytokine from mastocytes and leukocytes.

In the microscopic evaluation, cellular infiltration, dilatation of the gastric glands, ulcers, edema, hemorrhage and an increase in the number of mastocytes and eosinophils [4, 5, 11, 14, 17, 54, 89] are observed.

The cellular components involved in these interactions within the central nervous system (CNS) are mainly mastocytes, also called mast cells, and glia.

Advanced GCTs were associated with decreased T-cell and NK-cell signatures, while T-regs, mastocytes, and macrophages proved to be activated in patients with advanced stage disease.

Caption: Figure 2: Effects of alcohol and high-fat diet on the total amount of cells (a), number of mastocytes (b), and mast cells in the scar tissue of HF + AL (c) in skin wounds of Wistar rats.

Biopsy specimens of pericarotid tissues and carotid adventitia revealed nonspecific chronic inflammation with proliferation of fibroblasts, lymphocytes, mastocytes, and eosinophils, without granuloma formation and without evidence of active infection [14, 15].

Review of the literature has suggested that serum tryptase may be considered as a new marker of the instability of atheromatous plaque with regard to the existence of mastocytes in heart tissue.

TLR5 recognizes bacterial flagellin and is expressed in different cell types, including monocytes, mastocytes, dendritic cells, and epithelial cells (8,9).

Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients.