18-Apr-2025
Uncovering the structural and regulatory mechanisms underlying translation arrest
Okayama UniversityPeer-Reviewed Publication
Translation, or the synthesis of proteins, is a complex process orchestrated by the ribosome. However, translation may be stalled by the interaction of the ribosome with ‘ribosome arrest peptides’ (RAPs). While translation arrest helps regulate downstream gene expression, precise mechanisms underlying RAP activity remain poorly understood. Researchers from Japan have now characterized RAPs from Escherichia coli and uncovered a novel mini-hairpin-shaped nascent peptide that induces translation arrest through a unique mechanism.
- Journal
- Nature Communications
- Funder
- MEXT Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science (JSPS) KAKENHI, Core Research for Evolutional Science and Technology (CREST) of the Japan Science and Technology Agency (JST), Research Support Project for Life Science and Drug Discovery (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED, Pioneering Research Initiated by the Next Generation (SPRING) of Japan Science and Technology Agency (JST), Ohsumi Frontier Science Foundation, Japan Foundation for Applied Enzymology, Takeda Science Foundation, Yamada Science Foundation, Senri Life Science Foundation