Cellosaurus MDA-MB-468 shPARG (CVCL_RA91)

Cross-references
Cell line name	MDA-MB-468 shPARG
Synonyms	shPARG MDA-MB-468
Accession	CVCL_RA91
Resource Identification Initiative	To cite this cell line use: MDA-MB-468 shPARG (RRID:CVCL_RA91)
Comments	Group: Triple negative breast cancer (TNBC) cell line. Population: African American. Knockout cell: Method=shRNA knockdown; HGNC; HGNC:8605; PARG. Omics: Poly-ADP-ribosylation by proteomics. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Mutation; HGNC; HGNC:9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line). Mutation; HGNC; HGNC:9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease	Breast adenocarcinoma (NCIt: C5214)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0419 (MDA-MB-468)
Sex of cell	Female
Age at sampling	51Y
Category	Cancer cell line
Publications	PubMed=29166620; DOI=10.1016/j.celrep.2017.10.106; PMCID=PMC5728415 Zhen Y.-L., Zhang Y.-J., Yu Y.-H. A cell-line-specific atlas of PARP-mediated protein Asp/Glu-ADP-ribosylation in breast cancer. Cell Rep. 21:2326-2337(2017)
Cell line databases/resources	cancercelllines; CVCL_RA91
Encyclopedic resources	Wikidata; Q54904644
Entry history
Entry creation	05-Mar-2018
Last entry update	19-Dec-2024
Version number	14

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