Pressley is a vegan and self-described animal lover. She says veganism has helped her become a better athlete.<ref>{{cite web |last1=Lupica |first1=Diana |title=Top Soccer Player Toni Pressley: 'Veganism Helped Me Become A Better Athlete'|url=https://www.plantbasednews.org/culture/pro-soccer-player-toni-pressley-reveals-veganism-become-better-athlete |website=plantbasednews.org |date=14 December 2017 |access-date=12 September 2019 }}</ref>

 

In August 2019, Pressley began treatment for [[breast cancer]].<ref>{{cite web |title=Orlando Pride Defender Toni Pressley Diagnosed with Breast Cancer |url=https://www.orlandocitysc.com/post/2019/08/07/orlando-pride-defender-toni-pressley-diagnosed-breast-cancer |website=www.orlandocitysc.com}}</ref><ref>{{cite web |last1=Poe |first1=Julia |last2=USA |first2=Pro Soccer |title=Orlando Pride defender Toni Pressley diagnosed with breast cancer |url=https://www.prosoccerusa.com/nwsl/orlando-pride/orlando-pride-defender-toni-pressley-diagnosed-with-breast-cancer/ |website=Pro Soccer USA |date=7 August 2019}}</ref>