MD 264 begins at the intersection of Ballard Rogers Road and Oyster House Road in Broomes Island. Ballard Rogers Road continues south to the end of the peninsula between Island Creek and the Patuxent River that contains the village of Broomes Island, a former oyster canning center. MD 264 heads north as a two-lane undivided road out of the village through a mix of farmland and forest toward the community of [[Island Creek, Maryland|Island Creek]], where the highway intersects Parkers Wharf Road and Williams Wharf Road. In the village of [[Mutual, Maryland|Mutual]], the state highway intersects the northern terminus of [[Maryland Route 265|MD 265]] (Mackall Road) and Laveille Road, which leads west to the historic home [[La Veille]]. North of Mutual, MD 264 passes west of [[Christ Church (Port Republic, Maryland)|Christ Church]], which with a founded date of 1672 is the oldest church in Calvert County. The state highway passes a spur of old alignment, Yoes Corner Road (unsigned MD 264A), and reaches its northern terminus at a [[directional crossover intersection]] with MD 2/MD 4 (Solomons Island Road) in Port Republic. There is no direct access between MD 264 and [[Maryland Route 765|MD 765]] (St. Leonard Road), which meets the northbound direction of MD 2/MD 4 at an adjacent [[right-in/right-out]] intersection.<ref name="Maryland HLR"/><ref name="Google Maps MD 264"/>