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Parasitology

Triple genome triumph

Nature volume 436, page 337 (2005)Cite this article

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There is welcome news for scientists working on sleeping sickness, Chagas' disease and visceral leishmaniasis: the genomes of the three trypanosome parasites responsible for these devastating illnesses have now been cracked. The sequences from Trypanosoma brucei, Trypanosoma cruzi and Leishmania major were published in last week's Science by an array of international research teams (Science 309, 416–422, 409–415, 436–442; 2005).

Treatment of sleeping sickness, for example, still relies on melarsoprol, a 50-year-old drug that is ineffective in a third of patients and kills 5% of those who take it. The high rate of fatal reactions is accepted because the disease is otherwise lethal. New therapies are clearly needed, and the availability of the parasite genomes is a step towards finding drug targets and vaccine candidates.

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  1. Declan Butler
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Butler, D. Triple genome triumph. Nature 436, 337 (2005). https://doi.org/10.1038/436337b

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