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Multilayered Heterogeneity of Glioblastoma Stem Cells: Biological and Clinical Significance

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Stem Cells Heterogeneity in Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1139))

Abstract

Glioblastoma is a primary tumor of the brain with a poor prognosis. Pathological examination shows that this disease is characterized by intra-tumor morphological heterogeneity, while numerous and ongoing genomic analysis reveals multiple layers of heterogeneity. Intra-tumor and patient-to-patient heterogeneity is underpinned by cellular, genetic, and molecular heterogeneity, which is thought to be key determinants of time to tumor recurrence and resistance to therapy. The key cell type believed to contribute to the establishment and ongoing evolution of tumor heterogeneity is a glioma stem cell (GSC) subpopulation. In this chapter, we review, highlight, and discuss controversies and clinical relevance of glioblastoma heterogeneity and its cellular basis. Characterization of how cancer stem cells (CSCs) behave is important in understanding how tumors are initiated and how they recur following initial treatment.

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Acknowledgements

TM is supported by grants from the Brain Foundation Australia and the CASS Foundation Australia.

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The authors have declared no conflicts of interest.

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Authors and Affiliations

  1. Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia

    Daniel V. Brown

  2. Department of Surgery, The University of Melbourne, Parkville, VIC, Australia

    Stanley S. Stylli, Andrew H. Kaye & Theo Mantamadiotis

  3. Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia

    Stanley S. Stylli & Andrew H. Kaye

  4. Department of Microbiology and Immunology, The University of Melbourne, Parkville, VIC, Australia

    Theo Mantamadiotis

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  1. Department of Pathology, Federal University of Minas Gerais, Department of Radiology, Columbia University Medical Center, New York, NY, USA, Belo Horizonte, MG, Brazil

    Alexander Birbrair

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Brown, D.V., Stylli, S.S., Kaye, A.H., Mantamadiotis, T. (2019). Multilayered Heterogeneity of Glioblastoma Stem Cells: Biological and Clinical Significance. In: Birbrair, A. (eds) Stem Cells Heterogeneity in Cancer. Advances in Experimental Medicine and Biology, vol 1139. Springer, Cham. https://doi.org/10.1007/978-3-030-14366-4_1

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