eprintid: 10052556 rev_number: 26 eprint_status: archive userid: 608 dir: disk0/10/05/25/56 datestamp: 2018-07-19 17:48:17 lastmod: 2021-10-05 00:22:53 status_changed: 2018-07-19 17:48:17 type: article metadata_visibility: show creators_name: Gurruchaga, H creators_name: Saenz del Burgo, L creators_name: Hernandez, RM creators_name: Orive, G creators_name: Selden, C creators_name: Fuller, B creators_name: Ciriza, J creators_name: Pedraz, JL title: Advances in the slow freezing cryopreservation of microencapsulated cells ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: G91 divisions: D16 divisions: G85 keywords: cryoprotectant (CPA), dimethylsulfoxide (DMSO), slow freezing, drug delivery, cell microencapsulation, alginate note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Over the past few decades, the use of cell microencapsulation technology has been promoted for a wide range of applications as sustained drug delivery systems or as cells containing biosystems for regenerative medicine. However, difficulty in their preservation and storage has limited their availability to healthcare centers. Because the preservation in cryogenic temperatures poses many biological and biophysical challenges and that the technology has not been well understood, the slow cooling cryopreservation, which is the most used technique worldwide, has not given full measure of its full potential application yet. This review will discuss the different steps that should be understood and taken into account to preserve microencapsulated cells by slow freezing in a successful and simple manner. Moreover, it will review the slow freezing preservation of alginate-based microencapsulated cells and discuss some recommendations that the research community may pursue to optimize the preservation of microencapsulated cells, enabling the therapy translate from bench to the clinic. date: 2018-07-10 date_type: published publisher: ELSEVIER SCIENCE BV official_url: https://doi.org/10.1016/j.jconrel.2018.05.016 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Review verified: verified_manual elements_id: 1559779 doi: 10.1016/j.jconrel.2018.05.016 lyricists_name: Fuller, Barry lyricists_name: Selden, Angela lyricists_id: BJFUL78 lyricists_id: ACSEL91 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Journal of Controlled Release volume: 281 pagerange: 119-138 pages: 20 issn: 1873-4995 citation: Gurruchaga, H; Saenz del Burgo, L; Hernandez, RM; Orive, G; Selden, C; Fuller, B; Ciriza, J; Gurruchaga, H; Saenz del Burgo, L; Hernandez, RM; Orive, G; Selden, C; Fuller, B; Ciriza, J; Pedraz, JL; - view fewer <#> (2018) Advances in the slow freezing cryopreservation of microencapsulated cells. Journal of Controlled Release , 281 pp. 119-138. 10.1016/j.jconrel.2018.05.016 . Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10052556/1/Selden_Gurruchaga%20et%20al%20%28revised%29%20accepted.pdf pFad - Phonifier reborn

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