Carr et al., "ALS2 mutations: juvenile amyotrophic lateral sclerosis and generalized dystonia," Neurology, vol.

The remaining 5-10% of the cases are considered familial (FALS) generally following an autosomal dominant inheritance pattern [7] due to mutations in a number of seemingly disparate genes, including SOD1 [8], ALS2 [9], SETX [10,11], SPG11 [12], FUS [13, 14], VAPB [15], ANG [16, 17], TARDBP [18-20], FIG4 [21], OPTN [22], ATXN2 [23], and C9ORF72 [24, 25].

For example, editing of ALS2 gene in maize (acetolactate synthase or ALS is a key enzyme in the biosynthesis of amino acids in plants and has been inhibited by sulfonylurea herbicides) allowed the creation of a mutant corn plant resistant to chlorsulfuron [33].