In these in silico simulations (10), each modeled patient's true glucose was measured hourly by simulated devices with defined bias and imprecision. The measured glucose concentrations were used to select insulin infusion rates according to the Yale (11) and University of Washington (UW) (12) treatment regimens.

In this example, however, the irreversibility might be called 'small' in that the final uncertainty in the position approaches zero as [Delta]V is made smaller and smaller - for we have dealt with a model that suffers from relatively slight instability.(9) Yet since the uncertainty in the final position is measured by the product of [Delta]V and T, significantly large uncertainties can result from extremely small imprecisions in the initial velocities.

The ESC /ACC also defined the acceptable imprecision (CV) at the 99th percentile as [less than or equal to] 10%, an imprecision goal not met by any current assay.

For each measurement procedure, day-to-day imprecisions were estimated simultaneously with Unassayed Chemistry Control 1 and Unassayed Chemistry Control 2 (unassayed reference materials 731 and 732, respectively; Bio-Rad) as control materials and two serum pools from routine patient samples having values near the values obtained in the control materials.

Between-day and total imprecisions at different boron concentrations are presented in Table 2.

When the two CV values are the estimated values for analytical imprecisions of the two methods, Pharmacia and Delfia respectively, this interval describes more correctly the expected distribution of 95% of the measured ratios, if analytical imprecision is the only source of variation.

Derived data shown here cannot be used by other laboratories working with assays with different imprecisions.

In the first case, the acceptance limits are defined by the inherent analytical imprecisions, and in the latter case the acceptance limits are defined by the analytical quality specifications.

His thesis is that the current definition of the term is "amorphous" and "inconsistent," and that until a more precise and accurate definition is accepted fascist studies will remain mired in imprecision and controversy.

To make the error estimations more robust, we used 2 different simulation models, 1 based on a gaussian distribution of total error and another that considered bias and imprecision separately.

We believe assays with imprecision up to a 20% CV may reasonably be used for diagnosis and/or risk stratification, This belief is based on the following arguments:

We evaluated assay imprecision using lyophilized control sera with three different concentrations of cTnI (0.57, 5, and 15 [micro]g/L) that were analyzed 10 times in one analytical run for the determination of within-run imprecision and 24 times on 24 different days for the determination of between-run imprecision.

Various models have been proposed to set requirements for imprecision in clinical laboratory sciences.

From a practical point of view, the improved reliability of general Deming regression comes at the cost of knowing (or determining) imprecision profiles for both test and comparative methods.