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ICAM-1 levels in the SPL 500s group were significantly lower than those in the Conv 500s group (p = 0.0039) on day 1.

MCP-1 levels in the Conv 500s group dramatically increased and then decreased.

At day 1, the levels in SPL 500s and SPL 1000s groups were significantly lower (p = 0.0016 and p = 0.038, resp.) than those in the Conv 500s group.

In our data, the total number of spots in the SPL group was 2.4 times more than that in the Conv group.

In our clinical study, the average power intensity was 257 mW and 414 mW, and the pulse duration was 200 ms and 20 ms in the Conv and SPL groups, respectively.

Moreover, the photocoagulated eyes of rabbits showed that the protein concentration in the aqueous humor in the SPL group was less than that in the Conv group.

In our case series, the onset of NVI and NVG was not observed, and no significant differences were not noticed in the ratio of vitreous hemorrhage and the number of the additional laser treatment between the Conv group and the SPL group during the follow-up period.