Downstream effects of maternal hypothyroxinemia in early pregnancy: nonverbal IQ and brain morphology in school-age children.

In the second, but not the first, trimester, isolated hypothyroxinemia was significantly related to increased GDM risk (adjusted odds ratio, 2.97 comparing hypothyroxinemic with euthyroid women).

Treatment of subclinical hypothyroidism or hypothyroxinemia in pregnancy.

Iodine deficiency during pregnancy has been associated with maternal hypothyroxinemia that is related to growth, cognitive, and psychomotor deficit in neonates, infants, and children [6].

Mao, and et al., "High Body Mass Index Is an Indicator of Maternal Hypothyroidism, Hypothyroxinemia, and Thyroid-Peroxidase Antibody Positivity during Early Pregnancy," BioMed Research International, Article ID 351831, 2015.

Thanos, "Acute keratoconus induced by hypothyroxinemia during pregnancy," Journal of Endocrinological Investigation, vol.

Amodio et al., "Nutritional and prognostic significance of serum hypothyroxinemia in hospitalized patients with liver cirrhosis," Journal of Hepatology, vol.

As there is no benefit in treatment of isolated maternal hypothyroxinemia, universal FT4 screening during preconception is not recommended.

Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents.

ATLANTA -- Prenatal treatment of maternal subclinical hypothyroidism or hypothyroxinemia conferred no cognitive, behavioral, or neurodevelopmental benefit to children up to age 5.

Even though there is a state of hypothyroxinemia in normal pregnancy, it is more pronounced in pre-eclampsia.