GRIN2B

(redirected from GluN2B)

GRIN2B

A gene on chromosome 12p12 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN2B forms a complex with GRIN1, GRIN3A and PPP2CB; it interacts with HIP1, NETO1, MAGI3 and DAPK1, and with the PDZ domains of INADL and DLG4. It is highly expressed in the fronto-parieto-temporal cortex and hippocampus pyramidal cells.

Molecular pathology
Defects in GRIN2B cause mental retardation autosomal dominant type 8.
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References in periodicals archive ?
Closed head injury also resulted in transient decreases in GluN2A and GluN2B subunits of the NMDA receptor.
Aptinyx presents preclinical data on NMDA receptor modulator NYX-458
(6,7) The activity of NMDA receptor subunit 2B (GluN2B) contributes to vulnerability to neural excitotoxicity and psychiatric disorders, as well as working memory function in the prefrontal cortex.
Association between N-methyl-d-aspartate Receptor Subunit 2B Gene Polymorphisms and Personality Traits in a Young Japanese Population
Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases.
Mechanism of Repetitive Transcranial Magnetic Stimulation for Depression
GluN2A and GluN2B subunits have both been associated with LTP and cognitive function [22], and this is thought to be due to downstream activation of ERK [23].
Investigating the Interactive Effects of Sex Steroid Hormones and Brain-Derived Neurotrophic Factor during Adolescence on Hippocampal NMDA Receptor Expression
In addition, NL1 KO mice showed significantly reduced expression levels of NMDA receptor subunits GluN1, GluN2A, GluN2B and the AMPA receptor subunit GluA2 in synaptosomal hippocampal preparations [42].
Synaptic Plasticity and Excitation-Inhibition Balance in the Dentate Gyrus: Insights from In Vivo Recordings in Neuroligin-1, Neuroligin-2, and Collybistin Knockouts
Subsequent mechanistic studies found that under certain conditions NVP-AAM077 also could inhibit NMDARs containing the GluN2B receptor subunit, suggesting that the selectivity of this compound may not be as strong (Frizelle et al.
Mechanisms of neuroplasticity and ethanol's effects on plasticity in the striatum and bed nucleus of the stria terminalis
Phillips, "NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear," Neuropharmacology, vol.
The protective effect of Radix Polygoni Multiflori on diabetic encephalopathy via regulating myosin light chain kinase expression
GluN2B subunits are components of some NMDA receptors.
Longevity Gene May Boost Brain Power
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