AmiGO 2: Term Details for "canonical NF-kappaB signal transduction" (GO:0007249)

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Term Information

Accession: GO:0007249
Name: canonical NF-kappaB signal transduction
Ontology: biological_process
Synonyms: I-kappaB kinase/NF-kappaB cascade, I-kappaB kinase/NF-kappaB signal transduction, I-kappaB kinase/NF-kappaB signaling, canonical NF-kappaB signaling cascade, p50-dependent NF-kappaB signaling, NF-kappaB cascade
Alternate IDs: None
Definition: An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs). Source: PMID:12773372, PMID:34659217, GOC:bf
Comment: None
History: See term history for GO:0007249 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to canonical NF-kappaB signal transduction (excluding "regulates").; Link to all direct and indirect annotations to canonical NF-kappaB signal transduction (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for canonical NF-kappaB signal transduction (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical structure
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0141124 intracellular signaling cassette
GO:0007249 canonical NF-kappaB signal transduction
GO:0007252 I-kappaB phosphorylation
GO:0043124 negative regulation of canonical NF-kappaB signal transduction
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0043122 regulation of canonical NF-kappaB signal transduction

Parents of canonical NF-kappaB signal transduction (GO:0007249)

subject	relation	object
canonical NF-kappaB signal transduction	is_a	intracellular signaling cassette (GO:0141124)

Children of canonical NF-kappaB signal transduction (GO:0007249)

subject	relation	object
regulation of canonical NF-kappaB signal transduction (GO:0043122)	RO:0002211	canonical NF-kappaB signal transduction
symbiont-mediated suppression of host NF-kappaB cascade (GO:0085034)	RO:0012014	canonical NF-kappaB signal transduction
symbiont-mediated perturbation of host NF-kappaB cascade (GO:0085032)	RO:0002010	canonical NF-kappaB signal transduction
I-kappaB phosphorylation (GO:0007252)	BFO:0000050	canonical NF-kappaB signal transduction
positive regulation of canonical NF-kappaB signal transduction (GO:0043123)	RO:0002213	canonical NF-kappaB signal transduction
symbiont-mediated activation of host NF-kappaB cascade (GO:0085033)	RO:0012013	canonical NF-kappaB signal transduction
negative regulation of canonical NF-kappaB signal transduction (GO:0043124)	RO:0002212	canonical NF-kappaB signal transduction

Reactome: R-HSA-937072; R-HSA-5357956; R-HSA-9014325

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canonical NF-kappaB signal transduction