E 461 is a European B class road in Czech Republic and Austria, connecting the cities Svitavy, Brno, and Vienna.
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| Route information | |
| Length | 202 km (126 mi) |
| Major junctions | |
| From | Svitavy (Czech Republic) |
| Brno | |
| To | Vienna (Austria) |
| Location | |
| Countries |  Czech Republic Austria |
| Highway system | |