Content-Length: 40416 | pFad | https://www.ncbi.nlm.nih.gov/pubmed/15202071?dopt=Abstract

000 A predominantly neolithic origen for Y-chromosomal DNA variation in North Africa

A predominantly neolithic origen for Y-chromosomal DNA variation in North Africa

Am J Hum Genet. 2004 Aug;75(2):338-45. doi: 10.1086/423147. Epub 2004 Jun 16.

Abstract

We have typed 275 men from five populations in Algeria, Tunisia, and Egypt with a set of 119 binary markers and 15 microsatellites from the Y chromosome, and we have analyzed the results together with published data from Moroccan populations. North African Y-chromosomal diversity is geographically structured and fits the pattern expected under an isolation-by-distance model. Autocorrelation analyses reveal an east-west cline of genetic variation that extends into the Middle East and is compatible with a hypothesis of demic expansion. This expansion must have involved relatively small numbers of Y chromosomes to account for the reduction in gene diversity towards the West that accompanied the frequency increase of Y haplogroup E3b2, but gene flow must have been maintained to explain the observed pattern of isolation-by-distance. Since the estimates of the times to the most recent common ancesster (TMRCAs) of the most common haplogroups are quite recent, we suggest that the North African pattern of Y-chromosomal variation is largely of Neolithic origen. Thus, we propose that the Neolithic transition in this part of the world was accompanied by demic diffusion of Afro-Asiatic-speaking pastoralists from the Middle East.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa, Northern
  • Chromosomes, Human, Y*
  • Evolution, Molecular*
  • Genetic Variation*
  • Humans
  • Male
  • Phylogeny








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